Mucinosis of the skin - causes, forms, diagnostics, treatment, photos
- 26 Jun 14:45
- Disease Of The Skin
Mucinose is commonly referred to as a group of skin dermatoses characterized by mucin deposits in derma tissues. Mucin - a substance gel-like consistency, which includes acidic polysaccharides.
- Contents 1 Causes of
- 2 Clinical
- 2.1 Diffuse form of the disease
- 2.1.1 Heneralyzyrovanaya myxedema
- 2.1.2 pretybialna myxedema
- 2.1.3 Myksedematoznыy lychen
- 2.1.4 Erythematous reticular mutsynoz
- 2.1.5 Mukopolysaharydoznыe syndromes
- 2.1.6Self-healing juvenile skin mucinose
- 2.2 Local forms of the disease
- 2.2.1 Follycular mucinose
- 2.2.2 Skin focal mucinose
- 2.2.3 Arctic papular mucinose
- 2.1 Diffuse form of the disease
- 3 Methods of diagnosis
- 4 Treatment of
- 4.1 Treatment by folk methods
- 5 Prevention and prognosis
- 6 Photo
Causes of development of
Normally, mucin is produced by epithelial cells in a limited amount, with increased mucin production, mucinosis develops.
Allocate the primary and secondary form of the disease. The causes of primary mucinoses are various hormonal disorders, diseases associated with disorders of metabolic processes.
Secondary mucinosis is a consequence of such diseases as:
- Malignant tumors of the skin, including lymphomas.
- Degas' atrophic malignant papule.
- Systemic diseases with connective tissue damage - dermatomyositis, lupus erythematosus, etc.
Clinical picture of
Symptoms and clinical picture of mucinose are dependent on the form of the disease.
Diffuse forms of the disease
Among the primary diffuse mucinoses are the following diseases.
For this condition, the dryness and pallor of the skin are characteristic. The skin becomes yellowish in color, it becomes cold to the touch. On the face of patients with miksedema a "firm" edema is formed, as a result, the face becomes like a mask. In this disease there is swelling and in the distal parts of the limbs, the skin may appear rash of papular elements of pink color.
In the mice, pretibial is often affected by the skin of the legs. In the foci of the defeat, the skin is densely shaped and has the appearance of an orange crust due to the enlarged follicle openings.
Miksedematous lychene is a rare form of cutaneous mucinose. This disease is more common in middle-aged women. A characteristic symptom of this form is the appearance of lignhenoid nodules of pink color. These rash appear on the background of squeezed-edema of the skin( the so-called mucosal edema).When you click on the swollen skin, a fossa is not formed, it can not collect the skin in the fold. The face of patients with miksedematoznom lichena becomes like a mask.
Erythematous reticular mucinose
This form of the disease is also called the Reme syndrome or plaque-like skin mucinosis. The main symptom is the appearance of areas of mesh erythema, often affects the skin on the chest. When exposed to the affected skin of sunlight, an intensification of the pathological process takes place.
This is a group of hereditary diseases, the common feature of which is the deposition of mucin in different organs. Clinical signs of these diseases are a lag in development, moreover, both in mental and in physical. For this form of the disease characterized by various cardiovascular pathologies, a decrease in immune status. On the skin of the patients there are signs of hypertrichosis( excessive hair growth).And women sometimes may develop hirsutism. The skin surfaces are dry, in the region of the distal limb parts there may be areas of mucosal edema.
Self-cleaning juvenile skin mucinose
Very rare form of the disease. Develops at a young age, after a few months is spontaneous. The clinical picture of this disease is characterized by the appearance of plaques, papules and nodules of small size on the scalp, chest and, less frequently, limbs.
Local forms of the disease
The following are the local varieties of mucinoses.
Follycular Mucinose or Mucosal Alopecia. For this form of disease characterized by the deposition of mucin in hair follicles( follicles) and sebaceous glands. The main symptoms are the appearance of a yellowish or flesh-colored follicular papules or scaly plaques that can reach 5 cm in diameter. The appearance of rash is accompanied by a severe itching. There are focal lesions and follicular mucinose on the scalp, neck or back in the blades. Due to the defeat of the follicles there is a hair loss, that is, focal alopecia develops.
It is accepted to allocate three forms of follicular mucinose. For the first self-resolving form of mucinose, the appearance of one( at least several) lesions is characteristic, which independently pass through 2-24 months. The second form of follicular mucinose is characterized by a steady flow. The disease proceeds for years, steadily progressing. The lesions of the foam eventually acquire the appearance of plaques over the skin that have a consistency of jelly. The third form of follicular mucinose is a secondary disease and develops against the backdrop of lymphoma. This form of mucinose is most commonly seen in patients over 50 years of age.
Skin Focal Mucinose
Skin focal mucinose manifests itself in the formation of a single yellowish papule. A papule can appear on the face, skin of the limbs or chest.
Articular Papular Mucinose
Articular Papular Mucinose is characterized by the appearance of solitary nodes or ring-shaped elements. Appearing rash on the skin of the back of the hands and forearms. Conditioned rash by the deposition of mucin in the tissues of the dermis. There were cells stored for years, without causing any systemic damage.
Diagnosis of skin mucinose is based on the study of clinical data and histological studies.
For histology take the material from the lesion's cells. When conducting research in tissues, a localized cluster of mucin appears.
It is important to differentiate mucinose from diseases such as scleroderma, various forms of alopecia( atrophic alopecia, androgenic alopecia in men and women), lymphoma.
The treatment of skin mucinose is selected individually, depending on the form of the disease, the presence of concomitant pathologies and the patient's condition.
When a myxedema requires correction of the hormonal background or the appointment of life-long hormone replacement therapy. Lichne myxoma is extremely poorly treated. Patients are prescribed corticosteroids and cytostatics, but treatment often only gives a temporary effect.
In the case of erythematous mucinosis, the Delagil, Rezohin or other hingaamine drugs are prescribed.
Follicular mucinose is treated with systemic corticosteroids. If the disease is a consequence of lymphoma, specific treatment is required. In focal mucinosis often resorting to surgical excision lesions.
Treatment by folk methods
Treatment with phytotherapy with mucinose can be used only as an add-on to the main therapy.
At mucinose of the skin folk healers recommend to prepare a mixture of liter of honey, 300 grams of crushed walnuts, 100 grams of powdered garlic, 50 grams of powdered dill seeds. Take the mixture on a tablespoon three times a day.
Prevention and prognosis of
Prevention of skin mucinosis is a regular follow-up of medical examination. If systemic diseases are detected, the prescribed course of therapy should be followed.
The prognosis for mucinose of the skin depends on the form of the disease. In most cases, the forecast is favorable. In the presence of a malignant course of diseases that cause mucinosis, the forecast is complicated.