Chronic generalized granulomatous candidiasis - symptoms, treatment
- 22 Jun 14:30
- Disease Of The Skin
The term "candidiasis" is used to denote diseases of the mucous membranes( including the lining of the internal organs) and the skin caused by the influence of the pathogenic fungi of the Candide family. In patients with impaired immunity, candidiasis can take generalized( common) over.
- 1 Causes of development of
- 2 Clinical picture of
- 3 Methods of diagnosis
- 4 Treatment of
- 5 Nutrition recommendations
- 6 Forecast and prevention
- 7 Photo
Causes of development of
All types of candida are caused by pathological effects of Candida fungi that are part of the group of opportunistic pathogensmicroorganisms. This type of fungus is widespread, microorganisms exist in the external environment - in the soil, on the crust and leaves of trees, on fruits and berries. Fungi are easy to detect on many household items. Therefore, hygiene in candidiasis is very important.
Moreover, fungi present on mucous membranes and skin of healthy people, without causing them any concern.
Candida mushrooms are yeast-shaped microorganisms that have a rounded shape and a size up to 5 microns. The fungi do not have a micelle, forming a so-called pseudo-mycelial, consisting of thin cells and devoid of a common shell. Living inside the epidermal cells, the fungi are quite effectively protected from the action of drugs, therefore, the treatment of candidiasis is often not sufficiently effective.
This type of fungus refers to aerobic microorganisms. For food, they are particularly active in absorbing sugar, which explains the high tropism of fungi to tissues, which contain a lot of glycogen. And also frequent cases of candidiasis in patients with diabetes mellitus.
Fungi grow actively at temperatures from 20 to 37 degrees. Favorable conditions for fungi are a moist environment, close to neutral( pH 5,8-6,5), however, fungi normally tolerate drying. At boiling fungi die immediately.
Candidiasis develops both due to infection by fungi from the outside and from the pathogenic reproduction of its own saprophytes. For the purchase of pathogenic properties by fungi certain conditions are necessary, related to the decrease of immunity.
Candidiasis in the generalized form tends to develop in attenuated patients. Among the factors to be attributed are:
- Immunodeficiencies - congenital or acquired;
- Parathyroid and thyroid gland pathology;
- Reducing the function of the adrenal glands;
- Pathology of functioning of the pancreas.
In addition, generalized form of candidiasis may develop in the context of a chronic shortage of certain trace elements, in particular zinc and iron. And also, with the individual intolerance to the antigens of the fungus. Also, candidiasis is very commonly found in pregnant women. What this can endanger your mother and baby can be found in this article.
Clinical picture of
The peculiarities of the course of candidiasis in the generalized form are.
Death of the disease at an early age. Polarity of lesions. With generalized candidiasis, several organs are affected. As a rule, it is a skin. On the skin, candidiasis manifests itself in the formation of granulomas or papular rashes, on the head may form bumps due to candida scarring of hair. In the generalized form of candidiasis, nails are often affected, the plates thicken, and the nail rollers are reddened and inflamed( abscess nail roller).
Almost always with generalized candidiasis there is a mucosal lesions. On the shells with candidiasis there is a characteristic whitish, densely tangled plaque. When removing the raid erosion opens. The peculiarity of the generalized form of candidiasis is the defeat of the internal organs. Fungi may be affected by the kidneys, intestines, lungs, spleen, liver.
Tendency to relapse. Generalized candidiasis almost always has a chronic course and manifests itself as periodic relapses. In most patients, over a period of several years, granulomatous candidiasis manifests itself only in the mucosal and skin lesions( oral candidiasis, vaginal candidiasis), and lesions of the fungus of the internal organs can begin to manifest themselves only until adolescence. Thus, generalized candidiasis has a long history and until the time of full disclosure of clinical manifestations of fungi affect the virtually the whole organism.
Low sensitivity to treatment. The generalized candidiasis is extremely poorly treated, the possibility of completely getting rid of the fungus is practically eliminated. Therefore, granulomatous candidiasis belongs to a group of incurable diseases, and improvement of the patient's condition is considered as a temporary remission.
The basis of diagnosis is the evaluation of the clinical picture and the conduct of laboratory tests. When studying a material( scratches from the mucous membrane or skin) under a microscope is a pseudomycese fungus and a large number of blastospores( lagging cells).
A culture study is performed to determine the species composition of the fungus. In addition, in the diagnosis process, serological reactions are used.
Treatment of chronic forms of generalized candidiasis is a long process. Antifungal agents are prescribed intermittent courses of 7-10 days. It is necessary to conduct 4-5 such courses with alternating drugs. In the intervals between courses of antifungal therapy, prescribe iodine preparations.
The use of a polyvalent vaccine prepared from yeast-like fungi has been shown to treat granulomatous candidiasis. In the event that a candidiasis is complicated by a bacterial infection, mixed fungal-bacterial vaccines are used.
For the treatment of candidiasis it is necessary to conduct and nonspecific immunotherapy. Assigned to the introduction of gamma-globulins, methyluracil, proggiozana and other similar drugs.
Since generalized candidiasis often develops against the background of endocrine pathology, consultation with the endocrinologist and the appointment of corrective therapy is required. According to testimony, the administration of insulin, thyroidin, parathyroid and other hormonal drugs is prescribed. For general strengthening of the body in the treatment of the fungus is prescribed vitamin therapy, preparations aloe, calcium, phosphorus. In case of severe granulomatous candidiasis, transfusion of donor blood, leukocyte mass, or plasma may be required.
For the treatment of the skin affected by the fungus, external drugs are used - antifungal creams, ointments, solutions. An effective method of treating a fungus is the administration of drugs is phonophoresis.
In most cases, in the generalized form of candidiasis, it is necessary to prescribe drugs for the normalization of the intestinal microflora - bifidumbacterin, colibacterin, lactobacillin.
A diet recommended for candidiasis, practically eliminates the use of foods that contributes to the growth of fungal activity. Patients should be excluded from nutrition sugar, sweet fruits, honey. More protein-rich foods with low fat content, vegetables, sour berries and fruits are recommended. More about how to eat properly with candidiasis is described here.
Forecast and prevention of
Forecasting with generalized candidosis is serious. The disease is considered incurable and can lead to the development of complications that lead to fatal outcome. Prevention of recurrence of candidiasis consists in careful observance of the recommendations of the doctor, the exclusion of self-treatment, compliance with the diet and the regime.